Methods for Synthesis of Hydrogel Networks: A Review

Abstract

Hydrogels are macromolecular networks that swell, but do not dissolve, in water. The ability of hydrogels to absorb water arises from hydrophilic functional groups attached to the polymeric backbone, while their resistance to dissolution arises from crosslinks between network chains. Many materials, both naturally occurring and synthetic, fit the definition of hydrogels. Crosslinked dextrans and collagens are examples of natural polymers that are modified to produce hydrogels. Classes of synthetic hydrogels include poly(hydroxyalkyl methacrylates), poly(acrylamide), poly(N-vinyl pyrrolidone), poly(acry1ic acid), and poly(vinyl alcohol).