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Abstract
Results obtained in the present work indicated that the Luminex assay is more sensitive than ELISA. The reactivity to the early antigens E6 and E7 was 37% versus 42% for HPV 16 and 21% versus 20% for HPV 18 among cervical cancer cases using ELISA. However, these ratios were 44% and 61%, respectively, for E6 and E7 HPV 16 versus 28% and 21% for E6 and E7 HPV 18 when using the Luminex technique. Data also indicated that HPV 16 and HPV 18 showed distinct profiles for the different antigens tested. Finally, the differences in antibody responses between cervical cancer cases and benign cases toward the different antigens were significant.
ACKNOWLEDGMENT
This work is supported by the grant of IMEC Unit. We are most grateful to Doctor Pawlita M, Waterboer T and Sehr P (DKFZ) Heidelberg Germany for providing all products and for their useful help. We thank Mss Suzanne Wall for revision of the manuscript.
Manuscript 3278
Notes
ND: not done.
*P values for the difference between cervical cancer cases and controls.
Differences are significant for P < 0.05.
**P = 0.001.
***P < 0.0001.