The Spatiotemporal Expression and Localization Implicates a Potential Role for SerpinB11 in the Process of Mouse Spermatogenesis and Apoptosis

Abstract

In this study, the spatiotemporal expression of SerpinB11 in the mouse testis from postnatal 1–60 d was checked, the SerpinB11 protein strongly localized in the intermediate spermatogonia, B-type spermatogonium, preleptotene spermatocyte, leptonema spermatocyte, zygotene spermatocyte, but weakly localized in the pachytene spermatocyte, diplotene spermatocyte, sphere sperm, and the apoptotic sperm was positive stained of SerpinB11 protein, the localization of cell cycle marker CDK4 and meiosis marker SCP3 were investigated, and the SCP3 and SerpinB11 colocalized in the intermediate spermatogonia, B-type spermatogonium, preleptotene spermatocyte. Taken together, these results suggested that SerpinB11 might involved in spermatogenesis and apoptosis.

Keywords:

• SerpinB11
• spatiotemporal expression
• localization
• spermatogenesis
• SCP3
• apoptosis