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ABSTRACT
Background. It is now necessary to determine ALK status in order to use targeted therapy. Aim: herein, we assess immunohistochemical profile of ALK protein in a series of Tunisian patients with pulmonary adenocarcinoma.
Materials and Methods. ALK protein expression was studied applying the D5F3 antibody with a fully automated Ventana CDx technique on a series of 19 patients.
Results. Positive ALK expression was found in one case (5.2%) corresponding to a papillary adenocarcinoma which showed a strong granular and homogenous cytoplasmic staining. The patient was a 30-years-old woman.
Conclusion. The frequency of positive ALK expression based on immunohistochemistry in our series was similar to that reported in the world literature.
Acknowledgment
Ethical standards were respected in this study. No personal patient information was used.
Funding
This study was supported by a grant from the Ministry of Public Health of Tunisia.