Comparison of nitric oxide level in Behçet’s disease patients with or without psychiatric comorbidity

ABSTRACT

Both Behçet’s disease (BD) and major depressive disorder (MDD) are diseases associated with nitric oxide (NO). We hypothesized that the comorbidity of MDD affects the levels of NO in BD. In this study, we investigate whether there was a difference in NO levels among BD patients with accompanying MDD, BD patients with no depressive symptoms and healthy control group. There was a significant difference in NO levels among BD and control group (P < 0.05). Also, there was a significant difference between the BD group with MDD and BD group without psychiatric comorbidity in terms of NO levels (P < 0.05). This study is interesting as it demonstrates that accompanying psychiatric comorbidity puts an additional NO burden on the shoulders of BD patients.

KEYWORDS:

• Behçet syndrome
• comorbidity
• major depressive disorder
• nitric oxide

Acknowledgments

The funding entities had no role in the design of the study, the collection and analysis of data, the decision to publish, or preparation of the manuscript.

Author declaration

Concept – A.K., S.Y.; design – A.K., M.H.O.; supervision – A.K.; resource – R.I.O.; materials – A.S.K., R.I.O., M.H.O.; data collection and/or processing – A.K., M.H.O.; analysis and/or interpretation – A.K., M.H.O.; literature search – A.K., M.H.O.; writing – A.K., S.Y., M.H.O.; critical reviews – A.K. All authors contributed to and have approved the final manuscript.

Disclosure statement

No conflict of interest was declared by the authors.

Additional information

Funding

The authors declared that this study has received no financial support.