Pristine Fullerene C₆₀: Different Water Soluble Forms—Different Mechanisms of Biological Action

A. K. Sirotkin Institute of Influenza Russian Academy of Medical Sciences, Saint Petersburg, Russia

V. V. Zarubaev Institute of Influenza Russian Academy of Medical Sciences, Saint Petersburg, Russia

L. N. Poznyiakova Institute of Experimental Medicine Russian Academy of Medical Sciences, Saint Petersburg, Russia

M. A. Dumpis Institute of Experimental Medicine Russian Academy of Medical Sciences, Saint Petersburg, Russia

T. D. Muravieva Institute of Laser Physics, Saint Petersburg, Russia

T. K. Krisko Institute of Laser Physics, Saint Petersburg, Russia

I. M. Belousova Institute of Laser Physics, Saint Petersburg, Russia

O. I. Kiselev Institute of Influenza Russian Academy of Medical Sciences, Saint Petersburg, Russia

L. B. Piotrovsky Institute of Experimental Medicine Russian Academy of Medical Sciences, Saint Petersburg, RussiaCorrespondence[email protected]

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Abstract

Aqueous fullerene preparations, namely complex of C₆₀ with polyvinylpyrrolidone (C₆₀/PVP) and molecular‐colloidal water solutions of C₆₀ (FWS) exhibit virocidal activity due to different mechanisms: C₆₀/PVP complexes act mainly on the lipid component of virus membranes, while the mechanism of virocidal action of FWS is mainly connected with the ability of fullerene to generate singlet oxygen under irradiation. In the first case, fullerene acts mainly as a membranotropic agent, whereas in the second case it acts mainly as a photosensitizer.

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Acknowledgments

This work was supported by ISTC grant #2592.

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Pristine Fullerene C₆₀: Different Water Soluble Forms—Different Mechanisms of Biological Action