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Abstract
Development of glucose sensitivity of hypothalamic feeding centers (LH and VMN) has been studied by recording the change in their electrical activity in response to a glucose challenge in rats of different age groups. Glucoresponse of LH in 13-15 day rats was significantly increased (unlike adults) in high-voltage (H) activity; in 20-23 day rats the response was significantly decreased (like adults). In 13-15 day rats there was some increase in H activity, which further increased in 20-23 day rats. The effects lasted for about an hour. It is concluded that the immature LH responds differently than the mature LH, and that the glucostatic mechanism matures around the weaning period.