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Abstract
Metal copper oxide nanoparticles (nano-CuO) are under mass production and have been widely utilized in many fields including catalysis, gas sensors, semiconductor materials, etc. The broad applications of nano-CuO have increased the possibility of risk to incidental exposure to the environment, and therefore, an in-depth investigation of their effects on live cells is required. This study investigated the impact of the nano-CuO on SH-SY5Y cells, and findings showed that the ratio of LC3-II/LC3-I was significantly increased in SH-SY5Y cells when the cells were treated with nano-CuO. However, if the autophagy inhibitor Bafilomycin A1 (Baf A1) was co-treated, the ratio of LC3-II/LC3-I was further improved. These outcomes might indicate that autophagy flux was permanently elevated by adding nano-CuO. Further results found highly activated levels of long noncoding RNAs (lncRNAs) under nano-CuO treatment. The data illustrate a mechanism that nano-CuO can promote autophagy and activate lncCyt b-AS/ND5-AS/ND6-AS in SH-SY5Y cells and have critical implications for nanoparticle biomedical applications.
Author contributions
Conceptualization: Zhanqiang Du; Methodology: Zhanqiang Du, Xueqing Chai; Formal analysis and investigation: Zhanqiang Du, Xiaolin Li, Xiuyi Yang; Writing - original draft preparation: Zhanqiang Du, Xueqing Chai, Xiaolin Li; Data Curation and Validation: Guogang Ren; Writing - review and editing: Zhuo Yang; Funding acquisition: Zhuo Yang; Resources: Zhuo Yang; Supervision: Zhuo Yang.
Disclosure statement
The authors declare that there are no conflicts of interest.
Data availability statement
All the data generated or analyzed during this study are available from the corresponding author on reasonable request.