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ABSTRACT
A recent publication in Science demonstrates the ability of prostate cancer cells to switch lineages from one that is dependent on androgen signaling to a cell type that is not. Known as lineage plasticity, this phenomenon is driven by the transcription factor SOX2 in RB1 and TP53-deficient prostate cancer. SOX2 is a potential prognostic marker and therapeutic target in castration resistant prostate cancer.
Disclosure of potential conflicts of interest
The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organization imply endorsement by the US Government.
Funding
This work was supported by the National Institute of Health (NIH) under grant 1ZIABC010547–14.
Agency: National Institute of Health (NIH)
type: Investigator-Initiated Intramural Research Projects (ZIA)
Project #: 1ZIABC010547–14
Application #: 9343646