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ABSTRACT
Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway. Phosphorylation of 4E-BP1 causes its release from eIF4E to allow cap-dependent translation to proceed. Recently, 4E-BP1 was shown to be phosphorylated by other kinases besides mTOR, and overexpression of 4E-BP1 was found in different human carcinomas. In this review, we summarize the novel findings on mTOR independent 4E-BP1 phosphorylation in carcinomas. The implications of overexpression and possible multi-function of 4E-BP1 are also discussed.
Abbreviations
| 4E-BP1 | = | Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 |
| mTOR | = | mechanistic target of rapamycin |
| S6K1 | = | S6 kinase 1 |
| PTX | = | Paclitaxel |
| PIN | = | prostate intraepithelial neoplasia |
| mTKIs | = | mTOR kinase inhibitors |
| TIEK | = | TOR- independent 4E-BP1 kinase |
Disclosure of potential conflicts of interest
No potential conflicts of interest were disclosed.
Author contributions
Qin X, Jiang B and Zhang Y designed and wrote the review. Zhang Y took responsibility for revising the manuscript and final approval of the version to be published.
Funding
This work was supported by National Nature Science Foundation of China 81270035 and Shanghai Pujiang Program 15PJ1404900 (Zhang Y).