http://orcid.org/0000-0001-9936-5090
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ABSTRACT
The FcαR receptor (CD89) binds to the constant region of Immunoglobulin (Ig) A to mediate mucosal immunity [1–2]. FcαR consist of five exons: two that code for the signal peptide regions S1 & S2, two for the extracellular regions EC1 and EC2, and the final exon for the transmembrane/cytoplasmic tail region [3]. Previously, we reported that the EC1 region plays an essential role for extracellular membrane localization of the receptor [4], where the absence of EC1 would prevent the variants from localizing to the cell surface, even with a full signal peptide. In the case of FcαR Variant 4 (lacking the S2 region only), there was some “leakiness” to membrane surface localization.
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Disclosure of potential conflict of interest
No potential conflict of interest were disclosed.
Additional information
Funding
This work was supported by the JCO1334i00050 grant from Joint Council Office, Agency for Science, Technology, and Research (A*STAR) in Singapore.
