The role of ferroptosis in endothelial cell dysfunction

ABSTRACT

Ferroptosis is a form of iron-dependent cell death caused by an excessive accumulation of reactive oxygen species and lipid peroxidation. The importance of ferroptosis in the occurrence and progression of various diseases is gradually being recognized; however, the exact biological effects and potential mechanisms of endothelial cell ferroptosis remain unclear. The endothelium forms the innermost layer of the blood vessels and lymphatic vessels. It acts as an important functional interface, responds to various pathological stimuli and causes endothelial dysfunction. Here, we review recent findings to elucidate the role of ferroptosis in endothelial cells under different pathophysiologic settings.

KEYWORDS:

• endothelial cell
• ferroptosis
• endothelial cell dysfunction
• ROS
• iron

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability Statement

All data generated or used during the study appear in the submitted article.

Additional information

Funding

This work was supported by the Natural Science Foundation of Jiangsu Province (BK20181227), Six talent peaks project in Jiangsu Province (WSN-126),Social Development Foundation of Jiangsu (BE2021694), Foundation of Health and Family Planning Commission of Jiangsu (H201644), Natural Science Foundation of China (81971817) and Cardiovascular Disease Clinical Research Center of Zhenjiang (SS2018008).