https://orcid.org/0000-0001-7862-4524
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ABSTRACT
Atherosclerosis (AS) is a chronic inflammatory disease, which leads to atherosclerotic rupture, lumen stenosis and thrombosis, and often endangers life. Circular RNAs (circRNAs) are a special class of non-coding RNA molecules, whose abnormal expression has been proved to be closely related to human diseases, including AS. Both the abnormal regulation of circRNAs and the sponging effect on miRNAs would lead to changes in gene expression in the form of epigenetic modification, ultimately leading to the formation of AS. CircRNAs can be used as peripheral blood markers of AS, and play an important regulatory role in the proliferation, migration, inflammation and apoptosis of vascular smooth muscle cells, endothelial cells and macrophage, which are key cells for the development of AS. The in-depth understanding of circRNAs in AS not only provides a new method for the diagnosis of AS, but also provides a new idea for the treatment of AS.
Acknowledgements
We would like to thank the National Natural Science Foundation of China (No.82274310), Anhui Science and Technology Department (No.2022e07020028), Anhui Education Department (KJ2021A0588, KJ2021A0606, gxgwfx2022019) and Anhui University of traditional Chinese medicine (No.2020rcZD001) for supporting the research of this project.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
The data that support the findings of this study are available on request from the corresponding author, the data are not publicly available due to restrictions.