B-cell ALL with SOX11 gene amplification associates with a worse outcome

ABSTRACT

Copy number variation (CNV) of certain genes in pediatric Acute Lymphoblastic Leukemia (ALL) impacts gene expression levels. Here, we aimed to investigate the potential prognostic utility of CNVs in pediatric B-ALL and T-ALL. Using genomics files representing cases from the TARGET-ALL-P2 dataset, genes commonly involved in ALL development were analyzed for CNVs. Case IDs representing increased copy numbers for SOX11, PDGFRB, and MDK represented a worse overall survival probability specifically for B-ALL (logrank p=0.021, p=0.0052, p=0.019, respectively). These data support the continued investigation of using CNVs for clinical prognostic biomarkers for pediatric B-ALL

KEYWORDS:

• Acute lymphoblastic leukemia
• SOX11
• copy number variation
• survival probabilities
• B-ALL

Abbreviations

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Acknowledgments

Authors thank USF research computing and Ms. Corinne Walters, f.or extensive support of the administrative aspects of approvals for dataset access. Authors thank the taxpayers of the State of Florida

Disclosure statement

No potential conflict of interest was reported by the author(s).

Author contributions

GA: Conceptualization; Formal analysis; Methodology; Visualization; Writing - review & editing.

MV: Conceptualization; Methodology; Visualization

TRD: Formal analysis; Methodology; Software.

MJD: Formal analysis; Methodology; Software.

MY: Formal analysis; Methodology; Software.

GB: Conceptualization; Methodology; Project administration; Resources; Supervision; Writing - review & editing.

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/15384101.2024.2306756

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.