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Original Articles

Functional Electrical Stimulation Changes Muscle Oxygenation in Patients with Chronic Obstructive Pulmonary Disease During Moderate-Intensity Exercise: A Secondary Analysis

, , , , , , & show all
Pages 30-36 | Received 18 Jun 2018, Accepted 13 Dec 2018, Published online: 01 Mar 2019
 

Abstract

We previously showed that functional electrical stimulation during cycle ergometry (FES-cycling) increased oxygen consumption (VO2), indicating that metabolism during exercise was increased. However, the effects on muscle oxygenation have never been studied. The aim of this secondary analysis was to analyse changes in muscle oxygenation during an FES-cycling session. Eight patients with chronic obstructive pulmonary disease who were participating in a pulmonary rehabilitation programme were enrolled. Each participant carried out 30 minutes of cycle ergometry with a constant load at 50% of peak oxygen uptake, either (i) with FES or (ii) without (Placebo-FES). Oxygenation of the vastus lateralis (VL) muscle over time was measured using near-infrared spectroscopy (NIRS) during both sessions. External power output on the cycle ergometer was the same in both conditions. There were no differences in dyspnoea between the groups, although the concentrations of deoxygenated haemoglobin and myoglobin (deoxy(Hb + Mb)) in the VL were significantly greater during Placebo-FES than FES-Cycling (respectively +212 ± 65% vs. +84 ± 29%; p < 0.001), as was the decrease in muscle oxygen saturation (StO2) (p < 0.001). When adjusted for VO2, there was a greater increase over time in the deoxy(Hb + Mb)/VO2 ratio during Placebo-FES than FES-cycling (p < 0.0001). FES-cycling could be a useful strategy to decrease muscular deoxy(Hb + Mb) and limit decreases in muscle StO2, however this should be confirmed in larger studies.

Acknowledgments

We thank Johanna Robertson and Jennifer Dandrea Palethorpe for translation and constructive criticism.

Disclosure of interest

The authors report no conflict of interest

Additional information

Funding

This work was supported by ADIR Association (Rouen, France) and GHAHR Association (Le Havre, France).

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