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Articles

Genetic Polymorphisms of CYP2C9/CYP2C19 in Chronic Obstructive Pulmonary Disease

, , , , , , , , , , & show all
Pages 595-600 | Received 17 Mar 2020, Accepted 04 Jun 2020, Published online: 05 Aug 2020
 

Abstract

Chronic obstructive pulmonary disease (COPD) is a high incidence in the elderly and significantly affects the quality of life. CYP2C9 and CYP2C19 play an important role in tobacco-related diseases and inflammatory reactions. Thus, we aim to investigate the association between CYP2C9/CYP2C19 polymorphisms and the risk of COPD. In this study, a total of 821 subjects were recruited which include 313 COPD cases and 508 healthy controls. Seven SNPs of CYP2C9/CYP2C19 were selected for genotyping. The odds ratios (ORs) and 95% confidence interval (95% CI) were calculated using logistic regression analysis to evaluate the association between COPD risk and CYP2C9/CYP2C19 polymorphisms. Our study showed that A allele of rs9332220 in CYP2C9 was associated with reducing COPD risk (OR = 0.64, 95% CI = 0.43–0.94, p = 0.021). And rs111853758 G allele carrier could significantly decrease 0.35-fold COPD risk compared with T allele carrier (OR = 0.65, 95% CI = 0.45–0.96, p = 0.027). Furthermore, sex-based stratification analysis showed that rs9332220 and rs111853758 polymorphisms were associated with the risk of COPD in males. This is the first study to investigate the association between CYP2C9 and CYP2C19 genetic polymorphisms and COPD risk, which may give a new perspective on the prevention and diagnosis of COPD.

Acknowledgment

We would like to thank all the patients and individuals in this study for their participation.

Conflict of interest statement

The authors declare that they have no competing interests.

Availability data and material

All the data regarding the findings are available within the manuscript.

Anyone interested in the information should contact the corresponding author.

Additional information

Funding

This study was supported by the Hainan Provincial Natural Science Foundation of China (No. 818QN315) and the National Natural Science Foundation of China (No. 81660013 and No. 81860015).

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