Health-Related Quality of Life and Daily Physical Activity Level in Patients with COPD- a Cluster Analysis

Abstract

Patients with chronic obstructive pulmonary disease (COPD) may have a limited level of physical activity in daily life (PADL) and health-related quality of life (HRQOL). The interrelationships of these variables should be measure by cluster analysis to characterize this population and enable rehabilitation programs to target each patient profile identified. This study investigates different phenotypes in COPD according to PADL and HRQOL. A cross-sectional study with cluster analysis was done, in which 76 people with COPD were submitted to measurements to characterize the sample on first day, followed by used of physical activity monitor, which was worn for 7 days. After 7 days, the six-minute walk test (6MWT) and HRQOL questionnaires were applied (St. George’s Respiratory Questionnaire). The main results: three phenotypes were identified (A, B and C), with phenotype A who exhibited an inactive physical activity level and HRQOL scores above the value deemed satisfactory, phenotype B those with active physical activity level and poor HRQOL scores, and phenotype C subjects with inactive physical activity level and HRQOL scores but the value is close to cutoff point. To conclude, three phenotypes were found, with one indicating disproportionality between PADL and HRQOL.

Keywords:

• Physiotherapy
• Quality of life
• COPD
• physical activity
• physiotherapy
• cluster analysis

Data availability statement

Data availability on university database.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) with process number 18/06970-5 and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ).

Notes on contributors

Marcela Maria Carvalho da Silva

Marcela Maria Carvalho da Silva: Literature search, Data collection, Study design, Analysis of data, Manuscript preparation and Review of manuscript and final approval of the version to be submitted.

Juliano Ferreira Arcuri

Juliano Ferreira Arcuri: Literature search, Study design, Analysis of data, Manuscript preparation and Review of manuscript and final approval of the version to be submitted.

Henrique Pott

Henrique Pott Jr: Study design, Analysis of data, Manuscript preparation and Review of manuscript and final approval of the version to be submitted.

Anna Claudia Sentanin

Anna Claudia Sentanin: Data collection, Manuscript preparation and Review of manuscript and final approval of the version to be submitted.

Francisco José Barbosa Zorrer Franco

Francisco José Barbosa Zorrer Franco: Study design, Analysis of data, Manuscript preparation and Review of manuscript and final approval of the version to be submitted.

Luiz Henrique Pessôa da Costa Trondoli

Luis Henrique Pessôa da Costa Trondoli: Study design, Analysis of data, Manuscript preparation, Review of manuscript and final approval of the version to be submitted.

Valéria Amorim Pires Di Lorenzo

Valéria Amorim Pires Di Lorenzo: Literature search, Data collection, Study design, Analysis of data, Manuscript preparation and Review of manuscript and final approval of the version to be submitted. All authors have significantly contributed, read and approved the manuscript.