Liposomes as Carriers of Anticancer Medicines

J. Równicka-Zubik Medical University of Silesia, Department of Physical Pharmacy, Jagiellońska 4, 41-200, Sosnowiec, Poland

I. Czopek University of Silesia, Institute of Chemistry, Department of Environmental Chemistry and Technology, Szkolna 9, 40-006, Katowice, Poland

A. Hartabus Medical University of Silesia, Department of Physical Pharmacy, Jagiellońska 4, 41-200, Sosnowiec, Poland

Z. Zawada Medical University of Silesia, Department of Physical Pharmacy, Jagiellońska 4, 41-200, Sosnowiec, Poland

M. Maciążek-Jurczyk Medical University of Silesia, Department of Physical Pharmacy, Jagiellońska 4, 41-200, Sosnowiec, Poland

A. Szkudlarek-Haśnik Medical University of Silesia, Department of Physical Pharmacy, Jagiellońska 4, 41-200, Sosnowiec, Poland

A. Sułkowska Medical University of Silesia, Department of Physical Pharmacy, Jagiellońska 4, 41-200, Sosnowiec, Poland

A. Kos University of Silesia, Institute of Chemistry, Department of Environmental Chemistry and Technology, Szkolna 9, 40-006, Katowice, Poland

M. Żądło University of Silesia, Institute of Chemistry, Department of Environmental Chemistry and Technology, Szkolna 9, 40-006, Katowice, Poland

W. W. Sułkowski University of Silesia, Institute of Chemistry, Department of Environmental Chemistry and Technology, Szkolna 9, 40-006, Katowice, Poland

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Abstract

The aim of the work was the successful encapsulation of etoposide (ETO) and vinorelbine (VIN). Liposomes made from dipalmitylphosphatidylcholine (DPPC), liposomes containing both drugs (DPPC/ETO/VIN) and control liposomes DPPC/ETO and DPPC/VIN were prepared by the mREV method at 328 K. Liposome entrapped drugs were separated from free drugs by ultracentrifugation. The degree of encapsulation of drugs into liposome vesicles DPPC/ETO, DPPC/VIN and DPPC/ETO/VIN was estimated using UV spectrofluorescence after ultracentrifugation. The phase transition temperature was determined for all types of liposomes. The encapsulation efficiency, which is a measure of the percentage of the total compound entrapped within the liposome, is also determined.

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Acknowledgement

This work was supported by the grants of Medical University of Silesia: KNW-1-050/P/1/0 and KNW-1-008/N/1/0.

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Liposomes as Carriers of Anticancer Medicines

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Liposomes as Carriers of Anticancer Medicines

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