A Novel Method for the Improved Skin Whitening Effect Based on Nanostructured Lipid Carrier

Hengfeng FanState Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing, P.R. China;Suzhou Key Laboratory of Biomedical Materials and Technology, Research Institute of Southeast University in Suzhou, Suzhou, P.R. China

Huafeng ZhouState Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing, P.R. China;State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing, P.R. China

Chaolong MaState Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing, P.R. China;Suzhou Key Laboratory of Biomedical Materials and Technology, Research Institute of Southeast University in Suzhou, Suzhou, P.R. China

Yiqing HuangState Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing, P.R. China;Suzhou Key Laboratory of Biomedical Materials and Technology, Research Institute of Southeast University in Suzhou, Suzhou, P.R. China

Yan LiState Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing, P.R. China;Suzhou Key Laboratory of Biomedical Materials and Technology, Research Institute of Southeast University in Suzhou, Suzhou, P.R. China

Qiang XiaState Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing, P.R. China;Suzhou Key Laboratory of Biomedical Materials and Technology, Research Institute of Southeast University in Suzhou, Suzhou, P.R. ChinaCorrespondence[email protected]

Abstract

The nanostructured lipid carrier (NLC) encapsulating two potent skin whitening ingredients was developed by our group for cosmetic and dermatological treatment. The particle showed spherical shape morphology under atomic force microscope, and the value of the zeta potential of the NLC was − 65.4 ± 4.3 mV. Good physical stability was observed by dynamic light scattering during 45 days’ storage, respectively. The skin whitening effect was improved when applying the NLC. Therefore, the NLC might be a potential delivery vehicle in dermal products.

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Acknowledgments

The authors thank Shanghai Kans Cosmetic Co., Ltd. for providing phenylethyl resorcinol and tetrahydrocurcumin. This work was supported by International Scientific Cooperation Project of the Ministry of Science and Technology of China (No. 2008DFB50060) and International Scientific Cooperation Project of Suzhou (No. SH201204).

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A Novel Method for the Improved Skin Whitening Effect Based on Nanostructured Lipid Carrier

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A Novel Method for the Improved Skin Whitening Effect Based on Nanostructured Lipid Carrier

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