Comparative Studies on Drug Delivery Behavior of Mesoporous Silicas

Abstract

In this work, we compared drug delivery behaviors of two different mesoporous materials, SBA-15 and MCM-41. For this work, mesoporous materials were modified with alkylsilane-containing secondary dialkylammonium ions (SAPH) and macrocyclic materials (DB24C8). The mesostructure and modified surface of mesoporous materials were characterized by muti-techniques. We used ibuprofen, lysozyme, and cytochrome c as the drug molecules. The photoluminescent spectra of releasing drug molecules from mesoporous materials showed controlled releasing behavior on adding base solutions. We found that the drug release behavior was strongly dependent on the pore size of the materials and the size of the drug molecules.

Keywords:

• SBA-15
• MCM-41
• modified mesoporous materials
• drug molecule
• enzyme
• controlled release

Acknowledgments

The work was done in part during CSH's oversea studies in University of California at Los Angeles (UCLA) in 2010–2011 under the subject, “Preparation and Application of Nanovalves Based on Periodic Mesoporous Organosilicas.” The work was supported by the Research Institute of Industrial Technology, Pusan National University (PNU), Korea. CSH thanks to Prof. Jeffrey I. Zink of UCLA and Dr. Wanping Guo of PNU for their helpful and valuable discussions on the work.

Funding

The work was financially supported by the National Research Foundation of Korea (NRF) Grant funded by the Ministry of Science, ICT, and Future Planning, Korea (Pioneer Research Center Program (2010-0019308/2010-0019482) and Brain Korea 21 Plus Program (21A2013800002)).