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Abstract
Pure nanodrugs (PNDs) is a newly designed drug materials, which is a carrier-free drug nanoparticles fabricated by the reprecipitation method. In the present study, the cytotoxicity of PNDs consisting of SN-38 dimer and podophyllotoxin dimer with size in the range 30–50 nm was evaluated in human cancer HepG2, KPL-4, and MCF-7 cells. It was observed that the cytotoxicities of PNDs were changed depending on the type of cells. In addition, PNDs coated with polysorbate 80 showed higher activity than free PNDs, which suggests that the surface state of PNDs was the one of the important factors to affect cytotoxicity.
Acknowledgments
This study was supported by The Asahi Glass Foundation and the JST program of Adaptable and Seamless Technology Transfer Program through Target-driven R&D and Grant-in-Aid for Scientific Research (A) (No. 25248044).
Additionally, we would like to thank emeritus Prof. Hachiro Nakanishi of Tohoku University, Prof. Minoru Ueda of Graduate School of Science, Tohoku University, and Dr. Koichi Baba of Graduate School of Medicine, Osaka University for productive discussions.