Influence of some spice food based bioproducts on human monocytic cells line type THP-1

ABSTRACT

Two biomaterials obtained by hydrodistilation from an indigenous Satureja hortensis plant (SHEO), and from the rhizoms of Zingiber officinale (ZOEO), purchased from Romanian market, were tested in order to evaluate their effect on monocytic cells line type THP-1. The first biomaterial, (SHEO), has practically no biological effect whereas the other bioproduct, (ZOEO) has a better effect in comparison to L-NAME and etoposide. Due to a mechanism which implies cells apoptosis the quantities of nitric oxide (NO)produced by THP-1 cells are reduced under ZOEO action.

KEYWORDS:

• Apoptosis cells
• NO inhibition
• spice food biomaterials
• THP-1 cell line

Notes

1 p53, known as TP53 or tumor protein, is a gene that codes for a protein that regulates the cell cycle and functions as a tumor suppression.