A novel crystal of kanamycin disulfate: Preparation, structure and hygroscopicity

Abstract

A new kanamycin disulfate compound with chair structure has been successfully synthesized by volatilization method. The structure of the compound kanamycin disulfate was determined by single-crystal and powder X-ray crystallography. The decline of hygroscopicity made the kanamycin easier to save.

Keywords:

• Crystal structure
• hygroscopicity
• kanamycin
• kanamycin disulfate

Acknowledgments

We thank the NMPA Key Laboratory for Research and Evaluation of Generic Drugs.

Disclosure statement

There are no conflicts to declare.

Additional information

Funding

This work is financially supported by the Chinese Pharmacopeia Commission (grant number 2014322).