ABSTRACT
Matrix solid phase dispersion (MSPD) is a rapid and flexible sample pretreatment method that accomplishes sample disruption, extraction, filtering and purification in one step and is especially suitable for solid, semisolid and viscous samples. More than 30 years have elapsed since it was first proposed, and there are many published reviews. However, there is no review on the use of MSPD to extract active compounds from natural products. In this review, the latest developments from 2015–2021 in MSPD microextraction techniques, including sorbents, elution solvents and assisted MSPD extraction, along with their applications in natural products, are systematically discussed and classified according to the structure of the active constituents, which mainly refer to phenolic acids, flavonoids, alkaloids, anthraquinones and terpenes.
Acknowledgments
This study was supported by the General Program of Public Welfare Research Project of Zhejiang Province (LGF18H280006), the Hangzhou Social Development of Scientific Research Projects (20191203B13), and the National Natural Science Foundation of China (81573552).
Disclosure statement
No potential conflict of interest was reported by the author(s).