Natural Fiber Based Antibacterial, Wound Healing Surgical Sutures by the Application of Herbal Antimicrobial Compounds

ABSTRACT

Surgical sutures are important components of surgical operation and protection against post-surgical infections. The current in vitro study is an effort to evaluate the effects of antibacterial finishes extracted from natural sources, i.e. plants and herbs on natural fiber-based suture materials. These bioactive compounds are derived from Azadirachta indica (AI), Cyamopsis tetragonoloba (CT), Calotropis procera (CP), Prunus persica (PP), and Berberis lycium (BL), etc. All finishes were obtained by direct extraction method, and their effect was studied in this research. Two types of natural fiber materials, e.g. silk suture (SS, non-absorbable) and catgut suture (CS, absorbable), were selected. Mechanical properties were evaluated after application of the finish with concentrations of 50% and 100%, respectively. Antibacterial testing was also conducted for different finishes on both types of sutures, which provide promising results. In both types of sutures, mechanical properties and antibacterial properties were improved after application of herbal finishes. This paper highlights the possibility of using natural fiber sutures and bioactive finishes for imparting antibacterial wound care properties. The natural fibers and finishes will be helpful for reducing toxic treatments of sutures, which are hazardous to the environment.

摘要

外科缝线是外科手术和防止术后感染的重要组成部分. 目前的体外研究旨在评估从天然来源 (即植物和草药) 提取的抗菌整理剂对天然纤维缝合材料的影响. 这些生物活性化合物来源于印楝 (AI)、四角环孢 (CT)、原养钙菌 (CP)、波斯李 (PP) 和枸杞小檗 (BL) 等. 所有油剂均采用直接萃取法获得, 并对其效果进行了研究. 选择了两种天然纤维材料, 例如丝线 (SS, 非吸收性) 和羊肠线 (CS, 吸收性). 使用浓度分别为50%和100%的面漆后, 对机械性能进行评估. 两种缝线的不同饰面也进行了抗菌测试, 结果令人满意. 在这两种类型的缝线中, 使用草药整理剂后, 机械性能和抗菌性能都得到了改善. 这篇文章强调了使用天然纤维缝合线和生物活性整理剂来提供抗菌伤口护理性能的可能性. 天然纤维和饰面将有助于减少对环境有害的缝线毒性处理.

KEYWORDS:

• Surgical sutures
• herbal treatment
• absorbency
• antibacterial
• growth inhibition %

关键词:

• 外科缝线
• 中药治疗
• 吸光度
• 抗菌
• 生长抑制率%

Acknowledgments

The result was obtained through the financial support of project: Optimization of performance and comfort properties of fire resistant knitwear (No. NRPU/HEC/8980), project: “Development Of Comfortable Compression Socks For Treatment Of Varicose Veins Or Chronic Venous Disease In Legs” under HEC project Establishment of Technology Development Fund (TDF) (No.TDF03-149) and Internal grant agency of Faculty of Engineering, Czech University of Life Sciences Prague (no. 2021:31140).

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the project: “Development Of Comfortable Compression Socks For Treatment Of Varicose Veins Or Chronic Venous Disease In Legs” under HEC project Establishment of Technology Development Fund (TDF) [(No.TDF03-149)]; Internal grant agency of Faculty of Engineering no. 2021:31140/1312/3108 “Experimental research of hybrid adhesive bonds with multilayer sandwich construction, Czech University of Life Sciences Prague.” [2021:31140/1312/3108]; project: Optimization of performance and comfort properties of fire resistant knitwear [(No.NRPU/HEC/8980)].