Focusing on Hippo Pathway in Stem Cells of Oral Origin, Enamel Formation and Periodontium Regeneration

ABSTRACT

Hippo pathway is a cellular regulatory pathway composed of core molecules such as MST1/2, LATS1/2, SAV1, MOB1A/B and downstream YAP/TAZ. Fully involved in regulating cell proliferation, differentiation, migration and apoptosis, the Hippo pathway is critical in regulating stem cells of oral origin, for instance, DPSCs and PDLSCs, enamel formation and periodontium regeneration. Here, we summarized the Hippo pathway involved in these progresses and concluded crosstalks of the Hippo pathway with BCL-2, ERK1/2, ROCK, TGF-β/BMP and Wnt/β-catenin pathways, hoping to provide foundation for further clinical therapy.

KEYWORDS:

• Hippo pathway
• stem cell
• enamel formation
• periodontium regeneration

Abbreviation

Table

Disclosure statement

No potential conflict of interest was reported by the author(s).

Author contributions

T. W: drafting of the article and drawing schematic figures; T. W, K. L and H. L: critical revision of the article; E. L: guidance of this project and preformation of the final approval of the version to be submitted.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China under grant Number 81970917.