Controversies around the function of LARP1

Andrea J. Bermana Department of Biological Sciences, University of Pittsburgh, Pittsburgh, USACorrespondence[email protected]

https://orcid.org/0000-0003-1217-7412

Carson C. Thoreenb Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, USACorrespondence[email protected]

https://orcid.org/0000-0003-1164-7224

Zinaida Dedeicc Department of Oncology, University of Oxford, Oxford, UK

https://orcid.org/0000-0002-7046-3815

James Chettlec Department of Oncology, University of Oxford, Oxford, UK

Philippe P. Rouxd Institute for Research in Immunology and Cancer (IRIC), Université De Montréal, Montreal, Quebec, CanadaCorrespondence[email protected]

https://orcid.org/0000-0002-5962-0250

Sarah P. Blagdenc Department of Oncology, University of Oxford, Oxford, UKCorrespondence[email protected]

https://orcid.org/0000-0001-8783-3491

ABSTRACT

The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP translation while others that LARP1 activates it. Here, we present opinions from four leading scientists in the field to discuss these and other contradictory findings.

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Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Controversies around the function of LARP1

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Controversies around the function of LARP1

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