https://orcid.org/0000-0001-6332-4035
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ABSTRACT
Background
Post-exercise muscle soreness and fatigue can negatively affect exercise performance. Thus, it is desirable to attenuate muscle soreness and fatigue and promote recovery even for daily exercise habits aimed at maintaining or improving health.
Methods
This study investigated the effects of dietary collagen peptides (CPs) on post-exercise physical condition and fitness in healthy middle-aged adults unfamiliar with exercise. Middle-aged males (n = 20, 52.6 ± 5.8 years) received the active food (10 g of CPs per day) or the placebo food for 33 days in each period of the randomized crossover trial (registered at the University Hospital Medical Information Network Clinical Trials Registry with UMIN-CTR ID of UMIN000041441). On the 29th day, participants performed a maximum of five sets of 40 bodyweight squats. Muscle soreness as the primary outcome, fatigue, the maximum knee extension force during isometric muscle contraction of both legs, the range of motion (ROM), and the blood level of creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) were assessed before and after the exercise load.
Results
The analysis set was the per-protocol set (n = 18, 52.6 ± 6.0 years) for efficacy and the full analysis set (n = 19, 52.8 ± 5.9 years) for safety. The visual analog scale (VAS) of muscle soreness immediately after the exercise load was significantly lower in the active group than in the placebo group (32.0 ± 25.0 mm versus 45.8 ± 27.6 mm, p < 0.001). The VAS of fatigue immediately after the exercise load was also significantly lower in the active group than in the placebo group (47.3 ± 25.0 mm versus 59.0 ± 22.3 mm, p < 0.001). Two days (48 hours) afterthe exercise load, muscle strength was significantly higher in the active group than in the placebo group (85.2 ± 27.8 kg versus 80.5 ± 25.3 kg, p = 0.035). The level of CPK did not change over time. The level of LDH increased slightly but was not different between the groups. No safety-related issues were observed.
Conclusions
These results showed that dietary CPs alleviated muscle soreness and fatigue and affected muscle strength after exercise load in healthy middle-aged males.
Abbreviations
| BDHQ | = | brief-type, self-administered, diet history questionnaire |
| CI | = | confidence interval |
| CPK | = | creatine phosphokinase |
| CPs | = | collagen peptides |
| CRO | = | contract research organization |
| FAS | = | full analysis set |
| Gly | = | glycine |
| Hyp | = | hydroxyproline |
| LDH | = | lactate dehydrogenase |
| PPS | = | per-protocol set |
| Pro | = | proline |
| ROM | = | range of motion |
| VAS | = | visual analog scale. |
Acknowledgments
The authors greatly appreciate the patience and dedication of the study participants. The authors would like to thank all the staff of CPCC Co., Ltd and Chiyoda Paramedical Care Clinic for completing this trial.
Disclosure statement
Nippi Incorporated employs K Kuwaba, M Kusubata, Y Taga, K Mizuno, and H Igarashi. None of the authors have conflicts of interest to declare.
Author contribution statement
K.K. and M.K. contributed to study conceptualization. Y.T. and H.I. contributed to material preparation. K.K. contributed to visualization and presentation of data and writing the initial draft for publication. M.K., K.M., and K.N. contributed to interpretation of the results and discussion. All authors reviewed and revised the manuscript draft and approved the final version for submission.
Data availability
The datasets are available from the corresponding author on reasonable request.
Ethics statement
The study protocol was approved by the Ethics Review Committee of Chiyoda Paramedical Care Clinic (approval number: 20022102). All participants gave written informed consent prior to study participation. The trial was carried out in compliance with the Declaration of Helsinki, the Ethical Guidelines for Medical Research Involving Human Subjects (Ministry of Health, Labour and Welfare of Japan 2015), and the study protocol.
Supplementary material
Supplemental data for this article can be accessed online at https://doi.org/10.1080/15502783.2023.2206392