Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults

ABSTRACT

Introduction

Chronic pain affects 19% of adults in the United States, with increasing prevalence in active and aging populations. Pain can limit physical activity and activities of daily living (ADLs), resulting in declined mental and social health. Nutritional interventions for pain currently target inflammation or joint health, but few influence both. Collagen, the most abundant protein in the human body and constituent of the extra cellular matrix, is such a nutraceutical. While there have been reports of reductions in pain with short-term collagen peptide (CP) supplementation, there are no long-term studies specifically in healthy middle-aged active adults.

Purpose

To determine the effects of daily CP consumption over 3, 6, and 9 months on survey measures of pain, function, and physical and mental health using The Knee Injury & Osteoarthritis Outcomes Score (KOOS) and Veterans Rand 12 (VR-12) in middle-aged active adults.

Methods

This study was a double-blind randomized control trial with three treatment groups (Placebo, 10 g/d CP, and 20 g/d CP).

Results

Improvements in ADLs (p = .031, η_p² = .096) and pain (p = .037, η_p² = .164) were observed with 10 g/d CP over 6 months, although pain only improved in high frequency exercisers (>180 min/week). Additionally, VR-12 mental component scores (MCS) improved with 10 g/d of CP over 3–9 months (p = .017, η_p² = .309), while physical component scores (PCS) improved with 20 g/d of CP over 3-9 months, but only in females (p = .013, η_p²= .582).

Conclusion

These findings suggest 10 to 20 g/d of CP supplementation over 6 to 9 months may improve ADLs, pain, MCS, and PCS in middle-aged active adults.

KEYWORDS:

• Gelatin
• hydrolyzed
• KOOS
• VR-12
• nutrition
• connective tissue

Acknowledgments

We thank PB Leiner, part of Tessenderlo Group, who funded this study and provided the collagen supplement SOLUGEL® that was used in this study. We also thank Dr. Arjmandi for his contribution to the development of this study design, as well as the ISSM graduate and undergraduate student interns and volunteers, especially, Brett Hanna, Haylee Colannino, Kathryn O’Connor, and Anna Hayward. Lastly, we thank our study participants who made this study possible.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The work was supported by the Tessenderlo Group. Funding for this study was provided by PB Leiner, part of Tessenderlo Group. No outstanding grants remain with this company for any of the authors. The authors have no additional conflicts of interest to report. The results of the present study do not constitute endorsement by ACSM. The results of this study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation.