Association of PTPN22 Gene Polymorphisms with Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population

ABSTRACT

Juvenile idiopathic arthritis (JIA), the most common cause of chronic arthritis in children, is a complex immune-mediated disease with considerable long-term morbidity and mortality. According to previous studies, PTPN22 gene has been associated with JIA in several populations. In the present study, we attempted to determine the association of PTPN22 single nucleotide polymorphisms (SNPs) with susceptibility to JIA in Iranian population. Using the Real-time PCR allelic discrimination method, samples consisting of 55 unrelated patients and 93 healthy controls were genotyped. Using Fisher exact test or Chi-square test, genotypic and allelic frequencies were estimated. The results of our study indicated a significantly decreased association of rs1310182 (OR = 0.59, 95% CI = 0.36 −0.97, p = 0.037) with JIA. This association may indicate a protective role for rs1310182 SNP against JIA. More research would be needed to elucidate the mechanistic role of this association.

KEYWORDS:

• Iranian population
• juvenile idiopathic arthritis
• PTPN22 gene
• SNPs
• real-time PCR

Acknowledgments

The authors would like to announce their appreciation to all contributors who have made the achievement of this study.

Funding

This work was supported by a research grant (22389) from Tehran University of Medical Sciences.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.