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Fetal and Pediatric Pathology Volume 40, 2021 - Issue 2
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Research Article

Utility of the Platelet-to-Lymphocyte Ratio in Diagnosing and Predicting Treatment Success in Preterm Neonates with Patent Ductus Arteriosus

Birol Karabuluta Department of Pediatrics, Division of Neonatology, Ataturk Training and Research Hospital, Izmir Katip Celebi University, Karabaglar, Izmir, Turkey; Correspondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0523-153X
ORCID Icon &
Baran Cengiz Arcagökb Depatment of Pediatrics, Division of Neonatology, Acibadem Mehmet Ali Aydinlar University, Altunizade, Istanbul, TurkeyORCID Iconhttps://orcid.org/0000-0002-4834-9127
ORCID Icon
Pages 103-112 | Received 03 Sep 2019, Accepted 03 Oct 2019, Published online: 09 Nov 2019
 
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Abstract

Background

We investigated the predictive ability of the platelet-to-lymphocyte ratio (PLR) in preterm infants to discriminate those with and without hemodynamically significant PDA (hsPDA and non-hsPDA), hsPDA defined by those requiring medical intervention.

Methods

This observational retrospective cohort study included premature neonates (<34 weeks gestational age) with routine complete blood counts in a neonatal intensive care unit.

Results

PLR values on the 1st, 2nd, 3rd, and 7th days of birth were higher and lymphocyte counts were lower in the hsPDA than in the non-hsPDA group. Plateletcrit (PCT) values on the 2nd and 3rd days of birth were lower in the hsPDA group. All hsPDAs closed with medical therapy.

Conclusions

PLR may be a supportive tool for predicting those preterm infants with PDAs requiring medical intervention. This may serve as a guide for future studies investigating the predictive value of PCT and PLR for hsPDA in preterm infants.

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