Investigation of Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Children with Wilson Disease

Ferit Durankuşa Department of Pediatrics, Göztepe Education and Research Hospital, Istanbul Medeniyet University, İstanbul, TurkeyCorrespondence[email protected]

Yakup Albayrakb Faculty of Medicine, Department of Psychiatry, Tekirdağ Namık Kemal University, Tekirdağ, Turkey

Yavuz Tokgözc Department of Pediatrics, Keçiören Education and Research Hospital, Health Sciences University, Ankara, Turkey

Ömer Faruk Beşerd Medical School, Department of Pediatric Gastroenterology, Cerrahpaşa University, İstanbul, Turkey

Ramazan Durankuşa Department of Pediatrics, Göztepe Education and Research Hospital, Istanbul Medeniyet University, İstanbul, Turkey

Sebahat Çama Department of Pediatrics, Göztepe Education and Research Hospital, Istanbul Medeniyet University, İstanbul, Turkey

Eda Sünnetçie Medical School, Department of Pediatrics, Acıbadem University, İstanbul, Turkey

Ömer Akarsuf Department of Microbiology, Göztepe Education and Research Hospital, Istanbul Medeniyet University, İstanbul, Turkey

Cemil Nuralg Department of Clinical Biochemistry, Medical Faculty, Yildirim Beyazit University, Ankara, Turkey

Özcan Erelg Department of Clinical Biochemistry, Medical Faculty, Yildirim Beyazit University, Ankara, Turkey

https://orcid.org/0000-0002-2996-3236

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Abstract

Background

The aim of the present study was to assess thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with Wilson Disease (WD) and to compare them to healthy controls. Methods: Based on the inclusion and exclusion criteria, fifteen children with WD and twenty-nine healthy children were enrolled, and serum thiol/disulfide and IMA levels were compared between groups. Results: The mean values of native and total thiols were significantly lower in the WD group than in the control group. The mean value of disulfide was significantly higher in the WD group than in the control group. The mean percentages of disulfide/total thiol and native thiol/total thiol were higher in the WD group than in the control group. The IMA value was also higher in the WD group than in the control group. Conclusion: The present study demonstrating altered thiol/disulfide parameters indicates increased oxidative stress in children with WD.

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The authors have no conflict of interest to declare.

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Investigation of Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Children with Wilson Disease

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Investigation of Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Children with Wilson Disease

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