Maternal Epilepsy and Umbilical Cord Blood Oxidative Stress Level

Abstract

Introduction

We investigated the effect of epilepsy on cord blood oxidative stress status.

Material and Methods

Thirty (n = 30) pregnant women with epilepsy and thirty (n = 30) healthy controls enrolled in this case control study. Albumin and IMA values and dynamic thiol/disulfide parameters were measured.

Results

Decreased native thiol and total thiol levels were found in the epilepsy group when compared to the control group (p: 0.001, p: 0.002). Higher IMA (p: 0.036) and lower albumin cord levels (P < 0.001) were measured in the epilepsy group with respect to the control group. Apgar scores at 1 and 5 miutes were lower in the epilepsy group (respectively; p = 0.012, p = 0.010). A negative correlation was found between IMA and cord pH value (r = 0.288 p = 0.034).

Conclusion

This study showed that epilepsy may alter thiol disulfide homeostasis and IMA levels.

Keywords:

• Epilepsy
• albumin
• ischemia modified albumin
• thiol-disulfide homeostasis
• oxidative stress

Data availability statement

The datasets that support the findings of this study are available from the corresponding author.

Disclosure statement

No potential conflict of interest was reported by the author(s).