Unilateral Anophthalmia and Congenital Frontal Cranioschisis Associated with Extradural Neuroglial Heterotopia: new Insights into a Possible New Malformative Spectrum

Abstract

Background: Neuroglial heterotopia, characterized by mature ­neuroglial tissue outside the central nervous system, has not been previously associated with cranioschisis. Case Report: A 4-year-old female patient, with left congenital anophthalmia, had a nasofrontal neuroglial heterotopia protruding through an ossification defect. Discussion: Nasofrontal cranioschisis may be associated with neuroglial heterotopias. The combination of anophthalmia and neuroglial heterotopia, previously described only once in the literature, may be part of a broader malformation spectrum that has not been properly characterized to date.

Keywords:

• Neuroglial
• heterotopia
• frontal
• ossification
• defect
• cranioschisis
• choristoma
• African;anophtalmia

Author contributions

All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.

Disclosure statement

There is no conflict of interest or external funding to declare. None of the authors have anything to disclose.

Institutional board review

After consultation, the institutional board review of our center does not require evaluation of individual clinical cases or retrospective studies based on isolated cases. All the information in this document has been anonymized in accordance with current legislation and does not allow patient recognition.

Original work

All authors of the manuscript declare that it is an original contribution, not previously published, and that at the present time it has not been sent to any other journal to assess its publication.

Funding

The author(s) reported there is no funding associated with the work featured in this article.