Abstract
Background: Langerhans cell histiocytosis (LCH) has heterogeneous presentations involving single or multiple systems, but simultaneous isolated skin and gastrointestinal involvement is not common. Case report: A female infant with intermittent bloody diarrhea was unresponsive for treatment of food allergy. Histology of gastric and colonic tissues demonstrated Langerhan’s cell histiocytosis. The infant also had red rashes that were histologically proven Langerhan’s cell histiocytosis. Chemotherapy utilized vincristine, cytarabine and prednisone. The bloody diarrhea and rash completely resolved with no recurrence in the 11 months of follow-up. Conclusion: Langerhan cell histiocytosis may present with simultaneous gastrointestinal and skin involvement.
Authors’ contributions
JF drafted the manuscript. JC and CD revised the manuscript. JL, TH, YL, YX and MW collected and analyzed the data. All authors read and approved the final manuscript.
Consent for publication
Written informed consent for publication was obtained from the patient’s parents.
Disclosure statement
The authors report there are no competing interests to declare.
Ethics approval and consent to participate
This study was performed according to the convention of the Declaration of Helsinki. Written informed consent was obtained from all the participants.