Carbon Nanomaterial Shows Drug Delivery Promise: Part 1—Selection of Carbon Nanomaterial and Drug Loading

Abstract

Carbon Nanofiber synthesized by Catalytic Chemical Vapor Deposition (CCVD) Method and purified with acid treatment was used as a drug‐loading vehicle. The surface area of these Carbon Nanofiber (CNF) was measured by a methylene blue method. Ball milling of purified CNF showed increased surface area. CNF was successfully loaded with four different molecules (aspirin, phenolphthalein, copper sulphate and an anticancer drug, doxorubicin hydrochloride). The work presented is a prelude to the direction of using carbon Nanomaterial as a vehicle of drug delivery to the desired sites. Analysis of loaded CNF by TEM, SEM, EDAX, IR and HPTLC confirmed the loading of drug and other tested molecules.

Keywords:

• carbon nanofiber
• surface area
• methylene blue
• centrifugal ball milling
• anti‐cancer drug

Acknowledgments

We are thankful to Mr. Sandesh Jaybhaye for providing the CNMs. Thanks are due to Dr Naresh Chandra, Principal Birla College and my colleagues of Chemistry department and Nanotech Research Lab for providing the necessary support. We would like to express our thanks to Anchrome Lab, Mulund for providing technical help.