Synthesis, Spectral and In Vitro Biological Studies of Bis‐Triorganogermyl(substituted)propionates of Triarylantimony(V) X‐ray Studies of Triphenylgermyl‐n‐propyl Propionic Acid

Abstract

New compounds of Bis‐triorganogermyl(substituted) propionates of triarylantimony(V) with general formula (¹R₃-GeCHR²CH₂CO₂)₂SbAr₃ have been synthesized and characterized by various techniques such as elemental analyses; FT‐IR, ¹HNMR, ¹³CNMR and mass spectrometry. All these compounds have distorted trigonal bipyramidal geometry around antimony in both solid states as well as in non‐coordinated solvents. The single X‐ray analysis of precursor triphenylgermyl‐n‐propyl propionic acid (Ph₃GeCH‐(n‐C₃H₇)CH₂COOH) have revealed dimeric structure of molecule through strong hydrogen bonding in conventional manner in which germanium has slightly distorted tetrahedral geometry. Selected numbers of compounds screened against different strains of bacteria and fungus show good activity.

Keywords:

• antimony carboxylates
• germanium
• X‐ray studies
• biological studies

Acknowledgments

We thank to Higher Education Commission, Islamabad, Pakistan for financial support through grant no. 20‐9/Acad‐R/2003