Synthesis, Characterization and Antimicrobial Studies of 1‐Furanyl‐2,4‐diaza‐1,3‐butandione Metal Complexes

Dimeric complexes of the type [MC1₂(fau)]₂ (where M=Mn(II), Co(II), Ni(II) or Zn(II) and fau=1‐furanyl 2,4‐ diaza‐1,3‐butanedione) have been synthesized. The ligand, fau, was also synthesized by the reaction of furanoyl chloride with urea. Molecular weight data, magnetic, conductivity measurements, elemental analysis, vibration, electronic, ¹H and ¹³C NMR spectra suggested octhedral geometries for all the complexes. The complexes were found to be dimeric and non‐ionic in methanol. Data also revealed evidence of metal‐metal bond. The ligand coordinates through 3 oxygen atoms. Zinc complex was found to be diamagnetic. The complexes were screened against four fungi and five bacteria in vitro and were found to be potentially active biocidals in the concentration range of 3.8–4.6 mg mL.⁻¹

Keywords:

• dimeric complexes
• 1‐furanyl‐2,4‐diaza‐1,3‐butanedione
• furanoyl chloride
• metal‐metal bond
• octahedral geometries
• active biocidals

The authors are grateful to The third World Academy of Science (TWAS), Triese, Italy for its financial support and an award of academic fellowship to one of us, which made the completion of this work possible at INQUIMAE, Departamento de Quimica Inorganica, Analitica y Quimica Fisica, Facultad de Ciencias Exactas Universidad de Buenos Aires, Argentina. The financial support of Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Argentina is acknowledged. Similarly we thank INQUIMAE, Departamento de Quimica Inorganica, Analitica y Quimica Fisica, Facultad de Ciencias Exactas Universidad de Buenos Aires, Argentina for making available its equipments and supply of chemcals used.