An Efficient One-Pot Synthesis of Novel Ethyl 2-((1H-Benzo[d]imidazol-2-ylamino)(Aryl)methylthio) Acetates Using Ni(NO₃)₂.6H₂O, as a Homogeneous Catalyst

Abstract

A one-pot multicomponent reaction of aldehydes, 2-amino benzimidazole and ethyl 2-mercaptoacetate is described as an efficient method for the synthesis of novel ethyl 2-((1H-benzo[d]imidazol-2-ylamino)(Aryl)methylthio)acetates in the presence of Ni(NO ₃ ) ₂ .6H ₂ O as a homogeneous catalyst at room temperature. The present procedure offers several advantages, such as high yields, short reaction times and very easy workup.

Keywords:

• 2-Amino benzimidazole
• catalyst
• one-pot reaction

We gratefully acknowledge the financial support from the Research Council of Arak University.

Notes

^aIsolated yield.

^bReaction was carried out under reflux conditions for 10h.

^aIsolated yield.

^bMelting points are not corrected.