Synthesis, Crystal Structures, and Biological Activity of Schiff Base Zinc(II) Complexes Derived From (2-piperidin-1-ylethyl)-(1-pyridin-2-ylethylidene)amine

Abstract

Two new similar zinc(II) complexes, [ZnI₂L] (1) and [Zn(NCS)₂L] (2), derived from the Schiff base (2-piperidin-1-ylethyl)-(1-pyridin-2-ylethylidene)amine(L), were prepared and structurally characterized by X-ray diffraction. The Zn atom in each complex is five-coordinated by the three N atoms of the Schiff base ligand, and by two I or N atoms of the terminal iodide or thiocyanate groups, forming distorted square-pyramidal coordination. The urease inhibitory activities of the complexes and the ligand were evaluated.

Keywords:

• crystal structure
• Schiff base
• synthesis
• urease inhibition
• zinc

Acknowledgments

This work was financially supported by the Natural Science Foundation of Jiangsu Province (BK2009640) and Open-end Funds of Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology (2010HS04).