Synthesis, Characterization, DNA Binding, and Cleavage Activity of New Co(III) and Ru(II) Complexes of Substituted Quinolines

Abstract

The cobalt(III) and ruthenium(II) complexes of the type [M(L)₂]ⁿ⁺ (M = Co(III) or Ru(II) ion, n = 3 for Co and 2 for Ru, L = 2-thiol/seleno 4-methylquinoline) were synthesized and structurally characterized. The spectral and magnetic data suggested octahedral geometry for all the complexes. DNA binding behaviors of these complexes with calf thymus DNA (CT-DNA) have been investigated by absorption spectra, viscosity, and thermal denaturation methods. The metal complexes intercalates into the DNA base stack. The oxidative cleavage activities of the complexes shows that the complexes act as potent nucleases.

Keywords:

• calf thymus DNA
• complexes
• intercalator
• oxidative cleavage
• quinolines