Lanthanide Complexes of 1-phenyl-3-methyl-5-hydroxypyrazole-4-carbaldehyde-(4′-hydroxybenzoyl) Hydrazone: Crystal Structure and Interaction Studies With Biomacromolecules

Abstract

1-phenyl-3-methyl-5-hydroxypyrazole-4-carbaldehyde-(4′-hyd roxybenzoyl) hydrazone and Ln(III) complexes have been synthesized and characterized. The interaction between these compounds and biomacromolecules was investigated by fluorescence and UV/vis absorption spectroscopy. The results suggested that the compounds caused fluorescence quenching of BSA through a static quenching procedure. Hydrophobic interaction force also played a major role in stabilizing the compounds. Moreover, interactions between calf thymus DNA and compound H₃L and its Ln(III) complexes were studied by spectroscopy and viscosity measurements. These studies showed that these compounds bind to DNA via an intercalation mode. Furthermore, antioxidant activities of compounds were determined by hydroxyl radical scavenging methods in detail.

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Keywords:

• antioxidant activity
• bovine serum albumin
• calf thymus DNA
• crystal Schiff base
• spectroscopy
• structure

Acknowledgments

This work is supported by the National Natural Science Foundation of China (20975046) and (81171337).