Abstract
Amodiaquine hydrochloride (AQ) is a 4-aminoquinoline derivative commonly used to prevent and treat malaria. Sodium N-chloro-p-toluenesulfonamide or chloramine-T (CAT) is a well-known oxidizing agent. In rhodium(III) chloride (Rh(III)) catalyzed oxidation, the rate law is -d[CAT] / dt = k [CAT]o [AQ]o [OH–]–x [Rh(III)]y and it takes the form -d[CAT]/dt = k [CAT]o[AQ]o[OH–]–x for uncatalyzed reaction, where x and y are less than unity. The rate constants revealed that the Rh(III) catalyzed reactions are about five fold faster than the uncatalyzed reactions. The catalytic constant (KC) and activation parameters with respect to Rh(III) catalyst have been deduced.
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Acknowledgments
Dr. Sukhdev thanks the Principal and the Management of MES College of Arts, Commerce and Science for encouragement.