Spectral and Biological Investigation for Cr(III), Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) Complexes With Optically Active Compound

Abstract

A series of complexes was prepared using optically active compound as ephedrine. Previously Cu(II)-ephedrine complex was prepared and completely different from that prepared in the study concerning the structural and molecular formula. The previous study on ephedrine was concerned on the optical activity for the chiral organic ligand. Here the author focuses on the coordination behavior of the ligand toward the metal ions. The mode of coordination was discussed based on IR and Raman spectra and suggested a neutral bidentate. The electronic spectra and magnetic measurements are coinciding for proposal geometry. The EPR spectral parameters confirm the square-pyramidal geometry of Cu(II) complex; the mass and ¹HNMR spectra of Cu(II) and Zn(II) complexes, respectively, support the molecular formula. The thermogravimetric analysis and the kinetic parameters were carried out for most complexes. The effect on DNA degradation was discussed on all prepared complexes in comparing with the free organic compound.

Keywords:

• DNA degradation
• ephedrine complexes
• EPR
• kinetics
• Raman
• thermal