Abstract
Manganese(II) and cobalt(II) react with cephalosporins antibiotics (cefazolin, ceftriaxone, and cefepime) plus sulfamethoxazole (Hsmz) to form the following mixed ligand complexes of general formulas [M(L)(smz)(H2O)2] (L1,2, L = monoanion of cefazolin HL1, ceftriaxone HL2; M = Mn(II), Co(II)) and [M(L3)(smz)(H2O)Cl] (cefepime L3), which were characterized by physicochemical and spectroscopic methods. The nature of bonding and the stereochemistry of the complexes have been deduced from elemental and thermal analyses, infrared, electronic spectra, magnetic susceptibility, EPR, and conductivity measurements. An octahedral geometry has been suggested for the complexes. Their spectra indicated that cephalosporins and Hsmz are acting as monoanionic bidentate chelating agents. They have been screened for their antibacterial activity and the results are compared with the activity of commercial cephalosporins.
Acknowledgments
The authors are grateful to Lic. Alfreisa Rodriguez for the antibacterial activity tests.