In Situ Room Temperature Synthesis and Characterization of Salicylaldehyde Phenylhydrazone Metal Complexes, Their Cytotoxic Activity on MCF-7 Cell Line, and Their Investigation as Antibacterial and Antifungal Agents

Abstract

In situ synthesis is usually used in industrial plants. As an approach new series of metal complexes of the salicylaldehyde phenylhydrazone, H₂L, have been synthesized and characterized by elemental analysis, IR, UV, ¹H-NMR, ¹³C-NMR and ESR spectra, magnetic susceptibility, and molar conductivity measurements. The spectral data and magnetic measurements of the complexes indicated that the geometries are either square planar or octahedral. All complexes showed low to moderate cytotoxic activity. The antibacterial and antifungal activities of the compounds showed that, all complexes showed higher antifungal activities than antibacterial activities. Nickel and copper complexes showed higher activity than the standard drug.

Keywords:

• in situ synthesis
• room temperature synthesis
• metal complexes
• Schiff base
• thermal analysis
• biological study
• cytotoxic activity