Schiff Base Copper(II) and Zinc(II) Complexes: Synthesis, Structures, and Antimicrobial Activities

Abstract

A new halo-substituted Schiff base ligand 2-bromo-6-[(2-ethylaminoethylimino)methyl]phenol (HL) and its copper(II) and zinc(II) complexes [Cu₂L₂(μ_1,1-NCS)₂] (1) and [ZnCl₂(HL)] (2) (HL is the zwitterionic form of the Schiff base ligand) have been prepared and characterized by elemental analyses, IR, and single-crystal X-ray crystallographic determination. The crystal of (1) is monoclinic: space group P2₁/c, a = 10.909(1), b = 13.976(1), c = 10.161(1) Å, β = 111.471(2)°, V = 1441.7(2) ų, Z = 2. The crystal of (2) is monoclinic: space group P2₁/n, a = 7.2682(4), b = 20.195(1), c = 10.8447(6) Å, β = 106.420(2)°, V = 1526.9(2) ų, Z = 4. The Cu atoms in the copper complex are in square pyramidal coordination. The Zn atom in the zinc complex is in tetrahedral coordination. The effect of the complexes on the antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans were studied.

Keywords:

• Schiff base
• copper complex
• nickel complex
• crystal structure
• antimicrobial

Supplementary Material

The crystallographic data of the structures described in this paper were deposited with the Cambridge Crystallographic Data Centre as supplementary publication no. CCDC- 945896 for (1) and 945897 for (2). Copies of these data are available free of charge from http://www.ccdc.ac.uk/conts/retrieving.html, or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: [phone]; or email: [email protected].

Additional information

Funding

This research was supported by the National Sciences Foundation of China (Nos. 20676057 and 20877036) and Top-Class Foundation of Pingdingshan University (No. 2008010).