Synthesis and Characterization of Bimetallic Post Transition Complexes for Antimicrobial Activity

Abstract

Antimicrobial and antibacterial activities of bimetallic complexes are very important in variety of biological mechanisms. In this research work, a Schiff base ligand 2-(bis-2-hydroxylphenylidene)-1,2-iminoethane was prepared by condensation reaction between the reactants. Using this ligand, the derivatives of post transition bimetallic complexes were also synthesized by condensation reaction between salicylaldehyde and ethylenediamine followed by transition metals (Cu, Co, Mn, Zn). The synthesized ligand was characterized by FT-IR, ¹H NMR, ¹³C NMR, and MS techniques, whereas the bimetallic complexes were characterized by FT-IR and X-ray crystallographic techniques. In a later stage, the ligand and bimetallic complexes were screened in vitro for antibacterial and antifungal activities by using disc diffusion method. Different bacterial strains such as Escherichia coli, Staphylococcus aureus, and Bacillus subtilis were used to check the antibacterial activities of ligand and bimetallic complexes. Similarly, the used fungal strains were Aspergillus flavus, Alternaria alternata, and Aspergillus niger. The biological activity data showed that the bimetallic complexes exhibit higher values of antibacterial and antifungal activities as compared with ligand.

Keywords:

• Schiff base
• transition metals
• salicylaldehyde
• ethylenediamine
• bacterial strains
• fungal strains

Acknowledgments

The authors would like to acknowledge the technical support of Dr M. Wakeel Ahsan, Chief Executive of Bhatti Scientifics Lahore, Pakistan, and Mr. Faisal Hameed from Biochemika International Lahore, Pakistan, throughout the conducted research work.