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Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry Volume 45, 2015 - Issue 12
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Original Articles

DNA Binding Properties of Water-Soluble Mixed Ligand Nickel(II) Complex with Calf-thymus DNA Using Different Instrumental Methods

Maryam BordbarDepartment of Chemistry, Faculty of Science, University of Qom, Qom, I. R. IranCorrespondence[email protected]
,
Masoumeh TabatabaeeDepartment of Chemistry, Islamic Azad University, Yazd-Branch, Yazd, I. R. Iran
,
Ali Yeganeh FaalDepartment of Chemistry, Payam Noor University, I. R. Iran
,
Zohreh Mehri LighvanDepartment of Chemistry, Isfahan University of Technology, Isfahan, I. R. Iran
&
Razieh FazaeliDepartment of Chemistry, Islamic Azad University, Shahreza-Branch, Shahreza, I. R. Iran
Pages 1882-1888 | Received 19 Sep 2013, Accepted 25 Feb 2014, Published online: 29 Jul 2015
 
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Abstract

The binding ability of the a water-soluble nickel(II) complex with pyridine-2,6-dicarboxylic acid (pydcH2) and 2-aminopyrimidine (amp) formulated as [Ni(pydc)(amp)].2H2O].H2O (1) to calf-thymus (CT-DNA) was investigated. The binding ability of 1 was studied by measuring the effects on the electronic absorption spectra, thermal denaturation studies, fluorescence quenching studies by using methylene blue (MB) as a fluoresce probe, and circular dichroism (CD) spectra. All the results suggest the interaction modes between 1 and DNA were partial intercalation with a binding constant of (8.43 ± 0.2) × 104 M−1.

Funding

Financial support from Department of Chemistry at Payame Noor University Qom center is gratefully acknowledged.

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