Nickel(II) complex of 4-amino-N-(2-pyrimidinyl)benzenesulfonamide: Synthesis, spectroscopic characterization, antimicrobial activity, crystal structure, and Hirshfeld surface analysis

ABSTRACT

A nickel complex of 4-amino-N-(2-pyrimidinyl)benzenesulfonamide (sulfadiazine) has been synthesized and characterized by elemental analysis, infrared, UV-Vis, and ¹H NMR spectroscopy. The title compound, [Ni(C₁₀H₉N₄O₂S)₂(C₅H₅N)₂](C₅H₅N)(H₂O)₂ crystallizes in monoclinic system with space group P2₁ and Z=2. X-ray analysis revealed that Ni(II) ion exhibits a distorted octahedral geometry. The Hirshfeld surfaces are performed to study the nature of interactions and their quantitative contributions toward crystal packing. The results of spectral and thermal data suggest that the binding of nickel atom to the sulfonamidic nitrogen is in agreement with the crystal structure determination. Nickel sulfadiazine presents different antibacterial behavior against Escherichia coli and Staphylococcus aureus strains.

KEYWORDS:

• Antimicrobial activity
• crystal structure
• Hirshfeld surface
• Ni complex
• spectroscopic analysis
• thermogravimetric study

Acknowledgments

The authors are thankful to Central Salt and Marine Chemicals Research Institute, CSMCRI, Bhavnagar, India, for collecting NMR and TGA data. They also acknowledge the help received from SICART, Vallabh Vidyanagar, India, for CHN and IR data.

Funding

The authors are thankful to DST-FIST, New Delhi, India, for funding toward the single crystal diffractometer facility at Department of Physics, Sardar Patel University, Vallabh Vidyanagar, India. Sanjay M. Tailor is thankful to UGC for RFSMS fellowship.